APOQUEL® (oclacitinib tablet)

APOQUEL is the #1 prescribed medicine for allergic itch

Effective for flea allergy, food allergy, contact allergy, atopic dermatitis.

Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including flea allergy, food allergy, contact allergy and atopic dermatitis. Apoquel delivers onset of relief within 4 hours. It effectively controls itching within 24 hours. Apoquel requires a prescription from your veterinarian, and is sold per tablet.

APOQUEL® (oclacitinib tablet) has been prescribed to more than 8 million dogs in need of fast and effective allergic itch relief.

• Provides onset of relief within 4 hours
• Effectively controls itch within 24 hours
• Safe for short term and long term usage
• Can be used along with many other common medications, including parasiticides, antibiotics, and vaccines
• Uniquely targeted to stop the itch with minimal negative impact on immune function
• Controls pruritus associated with allergic dermatitis and controls atopic dermatitis
• Sold per tablet

Relieve allergic itch with APOQUEL during an 8-week food trial: The first step in providing allergic itch relief during diagnostic testing. APOQUEL lets you establish and maintain allergic itch relief while allowing you to achieve a diagnosis Fast itch control improves quality of life while you conduct diagnostic trials Short half-life lets you "turn-on" and "turn-off" itch control during flea control and food trials

APOQUEL is not a steroid.

First medicine specifically designed to target canine allergic itch and inflammation. Works differently from steroids and cyclosporine.

• Nonsteroidal APOQUEL targets specific cytokines that cause itch and inflammation, relieving symptoms of allergic skin disease with minimal impact on the immune system.

Short-term steroid use can cause side effects. 55% of dog owners report side effects with steroids. The most common include: Excessive thirst and urination Increased hunger and appetite APOQUEL works differently than steroids. Side effects reported most often are vomiting and diarrhea Balancing the need for relief with the consideration of side effects can create an emotional roller coaster for pet owners How to dose APOQUEL: The dose of APOQUEL tablets is 0.18 to 0.27 mg/lb (0.4 to 0.6 mg/kg) APOQUEL should be given twice daily (BID) for up to 14 days of therapy and once daily (SID) thereafter for maintenance APOQUEL may be given with or without food APOQUEL may be discontinued without tapering For more information see dosing guide.

Safety:

The safety profile of APOQUEL is supported by pharmacovigilance data over 5 years

The overall adverse reactions incidence rate during a 5-year review is rare (more than 1 but less than 10 animals reacting per 10,000 treatments administered)

• The incidence rate of the most commonly reported individual adverse reactions (in decreasing order: vomiting, diarrhea, lethargy, anorexia and bloodwork changes) associated with the use of APOQUEL was very rare (less than 1 dog out of 10,000 treated)
• Results are consistent with pre-approval pivotal safety and efficacy studies. APOQUEL is performing as expected under field conditions

Safe to use in dogs 12 months of age and older.

Side effects were similar to placebo over short term

• Most common side effects in a short-term clinical trial included vomiting and diarrhea and were self-limiting

Can be used long term for maintenance therapy

Can be used concomitantly with many medications, including NSAIDs, anti-infectives, parasiticides, antifungals and allergen-specific immunotherapy

• The use of APOQUEL has not been evaluated in combination with other systemic immunosuppressants, such as corticosteroids and cyclosporine

Not for use in dogs with serious infections or for use in breeding, pregnant or lactating dogs

Indications:

Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

Important Safety Information:

Do not use APOQUEL^® (oclacitinib tablet) in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.